- UPCC 19115 - Pragmatic Phase III Randomized Trial of Proton versus Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial
To compare 2 types of standard care radiation treatment: photon and proton, to find out which type is best for treating non-metastatic breast cancer.
- Phase 3 Randomized Trial Comparing Overall Survival After Photon versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB Non-Small Cell Lung Cancer (NSCLC)
To compare the good and bad effects in terms of patient life span after these 2 different types of radiation therapy (photon versus proton) in combination with FDA-approved chemotherapy for lung cancer. This study will allow the researchers to know whether the proton therapy approach is better, the same, or worse then the usual photon approach in terms of survival.
- 20.0004 - The COVID-19 and Cancer Consortium (CCC19) Registry
To collect granular information on cancer patients infected with COVID-19.
- A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Durvalumab Monotherapy or in Combination With Bevacizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (EMERALD-2)
To assess the efficacy and safety of durvalumab in combination with bevacizumab or durvalumab monotherapy or placebo as adjuvant therapy. This study will be conducted in patients with HCC who are at high risk of recurrence after curative hepatic resection or ablation. 888 patients will be enrolled globally.
- 20091082 - Evaluation Tracking Project: A Prospective Chart Review of Patients Treated with Radiation Therapy
To collect & analyze information on people with similar cancer diagnosis. The effectiveness of procedures & treatments, the usefulness of various tests, and the incidence of short or long-term side effects will be evaluated. The ultimate goal is to improve effectiveness of treatments & procedures & limit side effects & late complications for patients.
- A Phase 3, Randomized, Double-blind, Multicenter Study of Dostarlimab (TSR-042) plus Carboplatin-paclitaxel versus Placebo plus Carboplatin-paclitaxel in Patients with Recurrent or Primary Advanced Endometrial Cancer
Determine the efficacy and safety of dostarlimab plus carboplatin-paclitaxel versus placebo plus carboplatin-paclitaxel in patients with recurrent or primary advanced (Stage III or IV) endometrial cancer.
- A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination with either Durvalumab Monotherapy or Durvalumab plus Bevacizumab Therapy in Patients with Locoregional Hepatocellular Carcinoma
To compare the efficacy of TACE with Duravalumab + Bevacizumab, TACE with Duravalumab alone and TACE only.
- A Phase 3, Randomized, Double-Blind Study of Pembrolizumab versus Placebo in Combination with Adjuvant Chemotherapy With or Without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative Intent. (GOG-3053)
The treatment of participants with newly diagnosed, high-risk EC following surgery with curative intent.
- Pivotal, open-label, randomized study of radiosurgery with or without Tumor Treating Fields (TTFields) for 1-10 brain metastases from non-small cell lung cancer (NSCLC)
To obtain information on the safety & effectiveness of the NovoTTF-100M (study device) in patients with brain metastases (tumors) from non-small cell lung cancer.
- Prospective Research Assessments in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
To examine how multiple myeloma is treated by doctors all over the world, how people respond to these treatments, & the economic impact of these treatments
- A Randomized, Double-Blind, Phase 3 Comparison of Platinum-Based Therapy with TSR-042 and Niraparib Versus Standard of Care Platinum-Based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer (3000-03-005/ENGOT-OV44)
To compare the progression-free survival (PFS) of patients with Stage III or IV ovarian cancer treated with platinum-based therapy, TSR-042, and niraparib to standard-of-care (SOC) platinum-based therapy.
- A Randomized Phase III Trial of Platinum Chemotherapy plus Paclitaxel with Bevacizumab and Atezolizumab versus Platinum Chemotherapy plus Paclitaxel and Bevacizumab in Metastatic (stage IVB), Persistent, or Recurrent Carcinoma of the Cervix. (GOG-3030)
To determine whether the addition of atezolizumab to chemotherapy and bevacizumab improves overall survival compared to chemotherapy plus bevacizumab in patients with metastatic persistent or recurrent carcinoma of the cervix
- A Prospective Comparative Study of Outcomes with Proton and Photon Radiation in Prostate Cancer (COMPPARE)
To determine if prostate cancer patients treated with proton therapy, as compared to IMRT, experience:
Improved quality of life
Reduced toxicity
Non-inferior or even superior cancer control
To determine if Hypofractionated proton therapy is non-inferior to standard fractionated proton therapy in patient-reported outcomes & physician-reported toxicity.