The Willis-Knighton TomoTherapy Unit was the 4th in the United States and only the 6th in the world. The department has been named a Center of Excellence for TomoTherapy and is specifically researching stereotactic radiotherapy and radiosurgery with the device.

TomoTherapy is a form of Intensity Modulated Radiation Therapy (IMRT) which is a clinically superior treatment in many cases due to the ability to minimize radiation to healthy tissues. TomoTherapy is designed to simplify the treatment process and minimize dose to sensitive healthy structures.