-- Robert Preidt
FRIDAY, March 15 (HealthDay News) -- A potential early indicator
of acute kidney injury has been identified by researchers.
Acute kidney injury is a common and serious complication of
hospitalization. It affects about 6 percent of all hospitalized
patients and 30 percent to 40 percent of adults and children who
undergo cardiopulmonary (heart-lung) bypass surgery, according to
the researchers from the Medical College of Georgia.
They also noted that 10 percent to 15 percent of acute kidney
injuries lead to chronic kidney disease or failure that may require
dialysis or a kidney transplant.
In animal and human studies, the researchers found that a
significant amount of the protein semaphorin 3A is detectable in
the urine within a few hours after acute kidney injury.
The protein is not usually measurable in urine, but it was
rapidly detected in a group of 60 children after they had
heart-lung bypass surgery. High protein levels were about 90
percent accurate at identifying the 26 children with acute kidney
In these children, levels of the protein in the urine were high
within two hours after surgery, peaked at six hours, and returned
to normal after 12 hours, according to the findings published
recently in the journal
"Semaphorin 3A appears to be a sensitive biomarker that we believe will give physicians an early and accurate heads up that their patient's kidneys have been injured so that damage can be minimized and potentially reversed with rapid intervention," study corresponding author Dr. Ganesan Ramesh, a kidney pathologist, said in a college news release.
The U.S. National Institutes of Health has more about the
kidneys and kidney problems.
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